The present invention relates to an application of povidone iodine (PVP-I) in the preparation of a medicine treating premature ejaculation, wherein the medicine is the compound consisting of PVP-I and any other biologically compatible carrier, such as PVP-I disinfectant or Andoful PVP-I disinfectant. The beneficial effect is: by experiment, PVP-I is proved to be able to increase patients' ILET and have a significant therapeutic effect for those suffering premature ejaculation.
