Disclosed is a liver specific delivery (LSD)-based entecavir antiviral prodrug, i.e., a nucleoside cyclic phosphate compound, and the application thereof. Specifically, disclosed are a compound as represented by formula (I) and isomers, pharmaceutically acceptable salts, hydrates, and solvates of the compound, and a corresponding pharmaceutical composition. Also disclosed is the application of the compound of the present invention, used separately or used in combination with other antiviral drugs, against viruses, especially the application against hepatitis B virus (HBV).本發明提供基於肝臟特異性遞送技術(肝遞送)(Liver Specific Delivery(LSD))的恩替卡韋抗病毒前體藥物核苷環磷酸酯化合物及應用。具體地，本發明提供了式I化合物及其異構體、可藥用鹽、水合物、溶劑化物，以及相應的藥物組合物。本發明還提供了本發明化合物單獨或與其它抗病毒藥物聯合在抗病毒中的應用，特別是在抗乙型肝炎病毒(HBV)中的應用。
