THIS INVENTION IS DIRECTED TO PHARMACEUTICAL COMPOSITIONS FOR TOPICAL ADMINISTRATION TO A MAMMAL, WHEREIN THE PHARMACEUTICAL COMPOSITIONS COMPRISE A SPIRO-OXINDOLE COMPOUND, AS AN ENANTIOMER, A RACEMATE OR A NON-RACEMIC MIXTURE, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF. THESE PHARMACEUTICAL COMPOSITIONS ARE USEFUL FOR THE TREATMENT AND/OR PREVENTION OF SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS. FIG. 1