Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as controlled release dosage compositions for hydrophobic active ingredients. In one aspect, the invention provides a pharmaceutical formulation comprising a therapeutically effective amount of a hydrophobic drug, an adjustable ratio of a non-cross linked hydrogel polymer and a non-gelling insoluble polymer. One example is a controlled release pharmaceutical composition which includes 1% to 80% of a therapeutically amount of cilostazol, 4% to 80% of a water-swelling hydrogel polymer, and 4% to 80% of a non-gelling insoluble polymer. In another aspect, a constant release profile of the pharmaceutical formulation is obtained. In another aspect, a zero degree release profile of the pharmaceutical formulation is obtained. Further, a method for treating intermittent claudication using the pharmaceutical formulation is provided.本發明之實施例大致提供藥物之組合物與製備口服藥學組合物的方法,例如疏水性有效成分的經控制釋放劑量組合物。於一態樣中,提供一種藥物配方,該藥物配方包含一有效治療量的疏水性藥物、一可調比例之非交聯水凝膠聚合物與一非凝膠不可溶聚合物。一實施例係提供一經控制的藥物配方,其包含1%至80%之有效治療量的西洛他唑,4%至80%的水膨脹水凝膠聚合物以及4%至80%的非凝膠不可溶聚合物。於另一態樣中,則獲得該藥物配方的恆定釋放曲線。於又一態樣中,則獲得該藥物配方的零級釋放曲線。此外,亦提供利用該藥物配方治療間歇性跛行的方法。
