Polymeric particles that can be loaded color-coded and sized for therapeutic and / or diagnostic applications and methods of preparation and use thereof
FRITZ, Ulf,FRITZ, Olaf,GORDY, Thomas A.,WOJCIK, Ronald,BLUMMEL, Jacques,KULLER, Alexander
申请号：
ES07874236
公开号：
ES2564151T3
申请日:
2007.10.26
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Color-coded polymeric particles comprising: an anionic acrylate-based hydrogel core； a multivalent metal compound that forms an ionic interaction with the acrylate-based hydrogel core； and an outer layer comprising one or more colorants and a polyphosphazene having the general formula (I): ** Formula ** where the value of n is an integer from 2 to ∞； R1 to R6 are independently selected from the group consisting of: an alkyl, aminoalkyl, haloalkyl, thioalkyl, thioaryl, alkoxy, haloalkoxy, aryloxy, haloaryloxy, alkylthiolate, arylthiolate, alkylsulfonyl, alkylamino, dialkylamino, substituted or unsubstituted comprising heterocycloalkyl one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorous, or a combination thereof, or heteroaryl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorous, and a combination thereof wherein the polymeric particles are they form as microspheres, each microsphere being produced in a size or size range and each size or size range having a visually distinctive color imparted to it by the one or more dyes to provide a visual indication of the size or size range of the specific microsphere.partículas poliméricas codificadas con color que comprenden: un núcleo de hidrogel a base de acrilato aniónico； un compuesto de metal multivalente que forma una interacción iónica con el núcleo de hidrogel a base de acrilato； y una capa externa que comprende uno o más colorantes y un polifosfaceno que tiene la fórmula general (I):**Fórmula** en donde el valor de n es un entero de 2 a ∞； R1 a R6 se seleccionan independientemente del grupo que consiste de: un alquilo, aminoalquilo, haloalquilo, tioalquilo, tioarilo, alcoxi, haloalcoxi, ariloxi, haloariloxi, alquiltiolato, ariltiolato, alquilsulfonilo, alquilamino, dialquilamino, sustituido o no sustituido que comprende alquilo heterociclo uno o más heteroátomos seleccionados de nitrógeno, oxígeno, azufre, fósforo, o una combinación de los mismos, o heteroarilo
