INSTITUT CURIE;MUSEUM NATIONAL D'HISTOIRE NATURELLE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
发明人:
DUTREIX, MARIE,SUN, JIAN-SHENG
申请号：
CA2662065
公开号：
CA2662065C
申请日:
2007.09.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.
