Disclosed are a c-Kit activation inhibitor, a skin whitening compound and a composition for skin whitening comprising the skin whitening compound as an active ingredient. The c-Kit activation inhibitor of the present invention is a flavone derivative selected from the group consisting of the compounds represented by Formulas 1 to 10. The flavone derivative inhibits activity of the c-Kit associated with melanin synthesis, melanocyte differentiation and maturity, etc. Accordingly, the above-mentioned flavone derivatives are useful as skin whitening compound, and the cosmetic compositions comprising the flavone derivatives as an active ingredient can be highly effectively used for skin whitening, for example treating melasma, freckles, etc.
