A two-stage teething mitten is provided that includes a fabric pocket definingan interior cavityadapted to enclose an infant hand. An opening is provided in the pocket toaccommodate theinsertion of an infant hand into the interior cavity. An elongate strap ispositioned on the pocketadjacent the opening for detachably securing about the circumference of awrist of the infanthand. A detachable teething member, which may take the form of a sleevedimensioned topartially enclose the pocket, a teething ruff that may be attached to theelongate strap, or a secondreplacement fabric pocket, is provided.