The present invention relates to a complex formulation of Eperisone sustained-release microspheres and Aceclofenac. More specifically, the present invention relates to a complex formulation including: Eperisone sustained-release microspheres which use one or more saccharides selected from microcrystalline cellulose, anhydrous lactose, starch, sugar, maltitol, or mannitol as a seed for the microspheres, and obtained by coating Eperisone, an acidifier, and a release-controlling polymer； and Aceclofenac. When the Eperisone sustained-release microspheres and Aceclofenac, one of a non-steroidal anti-inflammatory analgesic, are administered as a complex formulation, Eperisone maintains a certain level of solubility in the gastrointestinal tract while showing a synergistic effect with the Aceclofenac, and the concentration of Eperisone in the blood can be maintained consistently, thereby providing excellent bioavailability.본 발명은 에페리손 서방성 미립구와 아세클로페낙 복합제제에 관한 것이다. 더욱 상세히는 미립구 시드로서 미결정 셀룰로오스, 무수 유당, 전분, 설탕, 말티톨 또는 만니톨에서 선택된 1종 이상의 당을 사용하고 에페리손, 산성화제 및 방출제어 고분자를 코팅시킨 에페리손 서방성 미립구와 아세클로페낙을 포함하는 복합제제에 관한 것이다.
