CRYSTAL MODIFICATIONS OF ELOBIXIBAT

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专利权人:

发明人:

BOHLIN MARTIN,TJERNELD ERICA,VESTERMARK ANDREAS,Ymén Ingvar

申请号：

IN9825/DELNP/2015

公开号：

IN2015DN09825A

申请日:

2015.10.19

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-l,l-dioxido-5- phenyl-2,3,4,5- tetrahydro-l,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2- phenylethanolyl} glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-l and 2-PrOH-l. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.

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