Disclosed herein are novel compositions and methods for the inhibition of SEDs proteins. Such compositions and methods are useful, for example, for the treatment of bacterial infections. Also disclosed herein are methods of determining whether a test agent is an inhibitor of SEDs protein activity.Linvention porte sur un nouvel inhibiteur de protéines SED pour le traitement dinfections bactériennes. Linvention vise également à determiner si un agent à lessai est, ou non, un inhibiteur de lactivité des protéines SED.