PROBLEM TO BE SOLVED: To provide an inflammatory mediator production inhibition ability having an excellent transdermal absorbability, less side effects, and a high safety, and to provide an external preparation for skin containing the same.SOLUTION: An external preparation for skin for an inflammatory mediator production inhibitor is provided by acquiring extracts from plants selected from the group consisting of Celastraceae Elaeodendron, Euphorbiaceae Euphorbia, and Sapindaceae Dodonaea to acquire an inflammatory mediator (e.g., selected from the group consisting of IL-6, NO and prostaglandin) production inhibitor containing the same as an active ingredient, and further by combining this inflammatory mediator production inhibitor with an external preparation for skin.COPYRIGHT: (C)2015,JPO&INPIT【課題】経皮吸収性に優れ、副作用が少なく、且つ安全性の高い炎症性メディエータ産生抑制能及びそれを含有する皮膚外用剤の提供。【解決手段】ニシキギ科Elaeodendron属、トウダイグサ科Euphorbia属、及びムクロジ科Dodonaea属からなる群から選択される植物から抽出物を取得し、これを有効成分とする炎症性メディエータ(例えばIL-6、NO、及びプロスタグランジンからなる群から選択されるもの)の産生抑制剤を得、さらにこの炎症性メディエータ産生抑制剤を皮膚外用剤に配合して炎症性メディエータ産生抑制用皮膚外用剤とする。【選択図】図1
