Craig M. Crews,Hyun Seop Tae,Ashley R. Schneekloth,Taavi Neklesa,Thomas Sundberg
申请号：
US15480627
公开号：
US10145848B2
申请日:
2017.04.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.
