您的位置: 首页 > 农业专利 > 详情页

Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
专利权人:
发明人:
Craig M. Crews,Hyun Seop Tae,Ashley R. Schneekloth,Taavi Neklesa,Thomas Sundberg
申请号:
US15480627
公开号:
US10145848B2
申请日:
2017.04.06
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充