MODULATION DE LA FAMILLE DE RÉCEPTEURS À DOMAINE VPS10 POUR LE TRAITEMENT DE TROUBLES MENTAUX ET DU COMPORTEMENT

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专利权人:

H. Lundbeck A/S

发明人:

申请号：

EP16187227.0

公开号：

EP3165537A1

申请日:

2009.12.17

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioural disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention furthermore relates to methods of altering expression of said receptors in vivo.

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