A sorbent cartridge comprising one or more detachable modules. The sorbent cartridge can have one or more modules contained therein having connectors connecting each of the modules. One or more of the modules can be reusable and the sorbent materials therein recharged. The sorbent cartridge can include a module containing an anion exchange resin, such as zirconium oxide, downstream of zirconium phosphate in the sorbent cartridge to recapture phosphate anions that leach out of the zirconium phosphate.