A pharmaceutical composition for preventing or treating a disease associated with an increase in peripheral serotonin or intestinal aromatic amine and a method for screening a drug for preventing or treating a disease associated with an increase in peripheral serotonin or intestinal aromatic amine.
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for preventing or treating a disease associated with an increase in peripheral serotonin or intestinal aromatic amine, and a method for screening a drug for preventing or treating a disease associated with an increase in peripheral serotonin or intestinal aromatic amine. SOLUTION: A pharmaceutical composition for preventing or treating a disease accompanied by an increase in peripheral serotonin or an intestinal aromatic amine, which contains an agent that inhibits an aromatic amino acid decarbonase of an intestinal bacterium as an active ingredient. The composition in which the agent that inhibits the aromatic amino acid decarboxylase of enterobacteria is carbidopa or benserazide. [Selection diagram] None【課題】末梢セロトニンまたは腸内芳香族アミンの増加を伴う疾患の予防または治療用医薬組成物および末梢セロトニンまたは腸内芳香族アミンの増加を伴う疾患の予防または治療用薬剤のスクリーニング方法の提供。【解決手段】腸内細菌の芳香族アミノ酸脱炭酸酵素を阻害する薬剤を有効成分として含有する、末梢セロトニンまたは腸内芳香族アミンの増加を伴う疾患の予防または治療用医薬組成物。腸内細菌の芳香族アミノ酸脱炭酸酵素を阻害する薬剤が、カルビドパまたはベンセラジドである前記組成物。【選択図】なし