The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC-1 ion channel.本發明係關於適用於治療、緩解及/或預防神經肌肉病症,包括逆轉藥物誘導的神經肌肉阻斷之化合物。如本文中所定義之化合物較佳抑制ClC-1離子通道。