Cross-species-specific psmaxcd3 bispecific single chain antibody

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专利权人:

AMGEN RESEARCH (MUNICH) GMBH

发明人:

KUFER PETER,MANGOLD SUSANNE,KLINGER MATTHIAS,HOFFMANN PATRICK,STEIGER CAROLA,KISCHEL ROMAN,HAUSMANN SUSANNE,FLUHR PETRA,SCHALLER EVELYNE,LUTTERBUESE RALF,RAUM TOBIAS,RAU DORIS

申请号：

NZ60220911

公开号：

NZ602209A

申请日:

2011.04.01

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Discloses a bispecific single chain antibody molecule comprising a first binding domain which is capable of binding to an epitope of human and Callithrix jacchus, Saguinis Oedipus or Saimiri sciureus CD3&egr； (epsilon), wherein the epitope SEQ ID NO: 2 ( QDGNEEMGGITQTPYKVSISGTTVILT), SEQ ID NO: 4 (QDGNEEMGDTTQNPYKVSISGTTVTLT). SEQ ID NO: 6 (QDGNEEMGDTTQNPYKVSISGTTVTLT) or SEQ ID NO: 8 (QDGNEEIGDTTQNPYKVSISGTTVTLT) and comprises the amino acid sequence Gln-Asp-Gly-Asn-Glu and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA) wherein the antibody comprises specific CDR regions.

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