De Staat der Nederlanden; vert. door de minister van VWS; Welzijn en; Ministerie van Volksgezondheid
发明人:
Merijn Louis Marten Salverda,Peter André van der Ley
申请号：
US16702660
公开号：
US20200197308A1
申请日:
2019.12.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.
