The present invention relates to a method and composition for use in treating a condition that benefits from the reduction of hepatic and/or visceral fat, such as polycystic ovary syndrome in adolescent girls or women of childbearing age, involving the use of spironolactone, pioglitazone and metformin.本發明係關於用於治療可因肝臟及/或內臟脂肪減少而受益之病狀(例如青春期少女或育齡女性之多囊性卵巢症候群)之方法及組合物,其涉及使用螺內酯、吡格列酮(pioglitazone)及二甲雙胍。