您的位置: 首页 > 农业专利 > 详情页

Improved process for preparing rivaroxaban using intermediaries
专利权人:
SYMED LABS LIMITED
发明人:
DODDA MOHAN RAO,BUTHUKURI VENKAT REDDY
申请号:
ARP130101486
公开号:
AR090910A1
申请日:
2013.05.02
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
The single vessel process is conducive to the preparation of rivaroxaban in industry, or the use of intermediate media, the use of three-dimensional form of chemical elements or racemic mixture, with high performance and purity. Rivaroxaban is useful as an inhibitor of active coagulation form X (XA factor). Claim 1: Processing rivaroxaban, 5-chloro-n - [(5S) - 2-oxo-3 - [4 - (3-oxomorfollin-4-il) phenyl] oxazolidin-5-il] methyl] parathion-2-carboxamida in one container, preparation (1),Or a stereoisomerized isomer form or racemic mixture thereof, characterized in that (a) 5-chlorothiophosphate-2-carbonate formula (4) or a salt reacts with sulfuric acid of formula (5a) or (5b), R is a group of asphalt, cyclopentyl, halogenated tar, aralquilo, Or alternative or unsubstituted arilo; for the production of a formulated sulfuric acid compound (3),The position of R in the above definition; (b) reaction of the formula sulfonate compound (3) with the formula of 4 - [4 - [(5S) - 5 - (aminobenzene) - 2-oxo-1, 3-oxazolidin-3-il] phenyl] morphine-3-ona (2) or the form of stereochemical isomerization or racemic mixture or acid salt addition of both, Rivaroxaban (1) or stereochemical isomerization form or racemic mixture in the production formula. Claim 15: a formula sulfuric acid compound (3),Marked R is a set of asphalt, cyclomethane, halogen, aralquilo, or alternative or unsubstituted arilo.El proceso en un solo recipiente que es industrialmente ventajoso para la preparación de Rivaroxaban o una forma estereoquímicamente isomérica o una mezcla racémica de las mismas, con alto rendimiento y pureza, utilizando intermediarios. El rivaroxaban es útil como inhibidor de la forma activa de coagulación X (factor Xa). Reivindicación 1: Un proceso en un solo recipiente para preparar Rivaroxaban, 5-cloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorfolin-4-il)fenil]oxazolidin-5-il]metil]tiofeno-2-carboxamida, de fórmula (1), o una forma estereoquímicamente isomérica o una mezcla racémica de las mismas, c
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充