PROBLEM TO BE SOLVED: To provide an appearance change retardation tablet which can retard appearance change such as spotting or browning in a tablet containing at least one water absorptive amino acid or its salt and which can be easily manufactured in a short time, and to provide a manufacturing method of the same.SOLUTION: This invention provides a manufacturing method of an appearance change retardation tablet of which appearance change inhibitor is silicate comprises the steps of: mixing at least one water absorptive amino acid or its salt with the appearance change inhibitor granulating the mixture obtained by the mixing step and compressing the granules obtained by the granulating step into a tablet.COPYRIGHT: (C)2014,JPO&INPIT【課題】少なくとも1種の吸水性アミノ酸又はその塩を含有する錠剤における斑点や褐変といった外観変化を抑制することができ、かつ、容易に短時間で製造することができる外観変化抑制錠剤及びその製造方法の提供。【解決手段】少なくとも1種の吸水性アミノ酸又はその塩と、外観変化抑制剤とを混合する工程と、前記混合工程で得られた混合物を造粒する工程と、前記造粒工程で得られた顆粒を打錠する工程とを含み、前記外観変化抑制剤がケイ酸塩である外観変化抑制錠剤の製造方法等である。【選択図】なし
