A portable device for diagnosing medical conditions and/or physiological reactions includes internal sensors, cameras, mirrors, lasers, electronics, speakers and/or other components. Sensors may be mounted on one or more internal gimbals for stability. The device transmits data it obtains to be processed. Deep learning and other algorithms and tools may be employed to make a diagnosis, detect physiological reactions, or make other observations from data received from the device, as desired. Information from the analysis may be communicated to the device for display. In one embodiment, the device is in the shape of a common item such as a coffee cup. In another embodiment, the device is in the form of a musical instrument and is configured to sense a subject's reaction to music, beats, and/or other stimuli.