The present invention relates to implantable endoluminal prostheses and methods of using such devices in preventing clots migration to avoid ischemic strokes. The implantable endoluminal prosthesis is suitable for deployment from the aortic annulus to the aorta and comprises a self-expandable braided framework able to expand from a radially compressed state in a delivery configuration to a radially expanded state, and a radially collapsible valve body comprising an impermeable material. The self-expandable braided framework is formed of braided wires having a given diameter, and has a proximal end configured to extend toward the heart and a distal end configured to extent toward away from the heart and extending along an axis. The braided framework comprises a main tubular body at the distal end of the self-expandable braided framework, a neck at the proximal end of the self-expandable braided framework, a transition portion extending between the proximal end of the main tubular body and the distal end of the neck. The main tubular body 3 and the neck comprise a lumen in a cylindrical form with a circular cross-section and a constant diameter respectively, and the diameter of the main tubular body is larger than the one of the neck. The main tubular body, the neck and the transition portion consist of an integrated structure comprising plurality of layers of made of biocompatible material, being devoid of any impermeable cover layer, and forming a wall having a thickness. The valve body is placed within the lumen of the neck.本發明關於一種可植入腔內假體及使用此種裝置預防凝塊遷移以避免缺血性中風之方法。可植入腔內假體適於佈設從主動脈瓣環到主動脈,且包括一可自膨脹之編網狀格架及一徑向可摺之瓣膜本體,該可自膨脹之編網狀格架能夠從呈一運送組態的一徑向壓縮狀態膨脹成一徑向膨脹狀態,該徑向可摺之瓣膜本體包括一不透性材料。該可自膨脹之編網狀格架係由具有一給定直徑之複數編網狀之金屬線形成,且具有佈設成朝心臟延伸之一近端、及佈設成朝遠離心臟延伸之一遠端,並沿一軸線延伸。該編網狀格架包括該可自膨脹之編網狀格架遠端處之一主要管形本體、該可自膨脹之編網狀格架近端處之一頸部、延伸於該主要管形本體近端與該頸部遠端之間的一轉變部。該主要管形本體3及該頸部分別包括呈一圓柱型之一內腔,具有一圓形剖面及一固定直徑,且該主要管形本體之直徑較該頸部者大。該主要管形本體、該頸部、及該轉變部組成一整合結構,其包括由生物相容之材料製成之複數層且無任何不透性覆蓋層之,及形成具有一厚度之一壁。該瓣膜本體置放於該頸部之內腔內。1‧‧‧腔內假體37‧‧‧主動
