A perfusion catheter system comprises a main line, a first branch line having a tip at a distal end thereof, and a second branch line having a tip at a distal end thereof. The tip of the first branch line is heavier than the tip of the second branch line. The tip of the first branch line may be weighted. There may be a self-inflating balloon at the tip of the first branch line. There may be a self-inflating balloon at the tip of the second branch line. There may be a clamp disposed along the second branch line. The clamp may include a base, a clamping arm hingedly connected to the base, and an aperture extending through the base. The second branch line may extend through the aperture in the base.