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Should controls the magnetic nanometer Drug objects of Treatment thrombotic diseases with what
专利权人:
发明人:
华沐怡,華沐怡,杨闳蔚,楊閎蔚,吴禹利,吳禹利,蔡荣源,蔡榮源,马蕴华,馬蘊華,陈志平,陳志平
申请号:
TW101110199
公开号:
TWI510256B
申请日:
2012.03.23
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention discloses a magnetic nanodrug for treating thrombosis, which comprises a core formed of magnetic nanoparticles, a shell enveloping the core and made of carboxyl-functionalized polyaniline, and a thrombosis-treatment drug covalently bonded to the shell. The magnetic nanodrug of the present invention is non-toxic to vascular endothelial cells, has superior stability, features superparamagnetism, and can be uniformly dissolved in water. Therefore, the magnetic nanodrug for treating thrombosis can be guided by an external magnetic field to concentrate on a specified region and increase the effect of thrombosis treatment.本發明係一種應用於治療血栓性疾病的磁性奈米藥物,其包括有一磁性奈米粒子之核心、包覆於核心之外的羧基化聚苯胺高分子外殼層和以共價鍵結方式結合於外殼層上的治療血栓性疾病藥物,本發明提出的磁性奈米藥物對於血管內皮細胞並不會產生毒性、具有良好的藥物穩定性、可均勻的分散於水中,並具有超順磁性,因此可藉由外加磁場將藥物導引集中於特定部位,增加局部治療濃度,以提升治療效果。1‧‧‧核心層2‧‧‧外殼層3‧‧‧藥物
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