PHILIPPE CRINE,GUY BOILEAU,THOMAS P. LOISEL,ISABELLE LEMIRE,PIERRE LEONARD,ROBERT HEFT,HAL LANDY
申请号：
BRPI0811198
公开号：
BRPI0811198A2
申请日:
2008.05.12
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
A bone targeted alkaline phosphatase comprising a polypeptide having the structure : Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase； wherein V is absent or is an amino acid sequence of at least one amino acid； X is absent or is an amino acid sequence of at least one amino acid； Y is absent or is an amino acid sequence of at least one amino acid； Z is absent or is an amino acid sequence of at least one amino acid； and Wn is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kits and methods of use thereof.
