IM, HO TAEK,JEONG, MYOUNG KI,KIM, YONG IL,PARK, JAE HYUN,WOO, JONG SOO,CHO, HYUK JUN
申请号：
CA2929862
公开号：
CA2929862A1
申请日:
2014.11.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Disclosed is a pharmaceutical combination formulation comprising a first discrete part containing amlodipine and rosuvastatin and a second discrete part containing losartan, which exhibits improved dissolution rate and stability. The inventive combination formulation comprising amlodipine, losartan and rosuvastatin having different action mechanisms from one another can be effectively used to prevent or treat a cardiovascular disorder. Designed to minimize an interaction among active ingredients, the pharmaceutical combination formulation exhibits excellent storage stability and dissolution rates of amlodipine, losartan and rosuvastatin, and thus can be useful in pharmaceutical industries.
