The present invention is related to a hyaluronic acid composition with a binary mixture of hyaluronic acids having mainly different weight-average molecular weight and then different rheological，tissue scaffold，barrier and degradation properties in aqueoussolution‧The resulted compositions have demonstrated an optimal balance between adhesion，barrier，tissue scaffold and treating time on the treatment and prevention of IBD (inflammatory bowel disease) includes ulcerative colitis and crohn’ s disease‧Thus，the present inventive binary mixture exhibits a quick and lasting effect on the treatment and prevention of IBD which is very good thing indeed.本發明提供一種使用於炎症性腸疾病(IBD)治療和預防之透明質酸混合物，其中至少包含有兩種或兩種以上之透明質酸所混合，該兩種或兩種以上之透明質酸主要在於具有不同的重量平均分子量(Mw)，即兩種或兩種以上之透明質酸具有不同的流變，兼具組織支架與隔絕功能和在溶液中之降解性，所得的透明質酸混合物具有較佳的療效與時效性，用以針對在炎症性腸疾病(如：潰瘍性結腸炎、急性腸炎、慢性腸炎、克隆氏症、腸躁症或腸胃的傷口癒合)之治療與預防，達到兼顧治療速效及緩效之作用。
