I-Jong Wang,Wei-Ting Ho,Ting-Hsuan Chiang,I-Tsen Lin
申请号：
US13899297
公开号：
US20140073611A1
申请日:
2013.05.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The disclosure relates to a platform of using zebrafish in screening candidates for treating and/or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the disclosure uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and/or the regulation of eyeball size. These drugs are potential candidates for treating myopia and/or keratoconus disease.
