CORSI CAMILLA,WALTER HARALD,EHRENFREUND JOSEF,TOBLER HANS
申请号：
IN3776/DELNP/2008
公开号：
IN263071B
申请日:
2008.05.02
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to a novel process for the preparation of a compound of general formula (I): wherein R1 is H or d.4 alkyl and R2 is difluoromethyl or trifluoromethyl, which comprises reacting a compound of general formula (II): wherein R1 has the meaning given above and X is chloro or bromo, with a compound of general formula (III): wherein R2 has the meaning given above, in the presence of a base, a palladium catalyst and a ferrocenyl biphoshine ligand of the Josiphos type, the reaction being carried out in an ether solvent at a reflux temperature of at least 100 °C.
