Systems and methods are provided for degassing a medical device. In one embodiment, a flushing device is provided that includes a tubular member including first and second ends and a chamber therein. First and second ports are spaced apart from one another along the tubular member and communicate with the chamber. One or more sources of flushing fluid are connectable to the first and/or second ports to create a flushing circuit, e.g., delivering flushing fluid into the first port, through the chamber, and out the second port to remove air or other gases from the chamber. An introducing assembly carrying a stent-graft may be introduced into the chamber, flushed, and then transferred to a delivery device. Thereafter, the stent-graft may be introduced into a patient's body and deployed at a target location, such as the site of an abdominal aortic aneurysm.