Ｔ細胞非依存性抗原に対するＩｇＧ型抗体の製造方法、Ｔ細胞非依存性抗原に対するＩｇＧ型抗体を産生する遺伝子組換えカイコおよびその製造方法
- 专利权人:
- 发明人:
- 申请号：
- JP20110536130
- 公开号：
- JP5679217(B2)
- 申请日:
- 2010.10.12
- 申请国别(地区):
- 日本
- 年份:
- 2015
- 代理人:
- 摘要：
Provided is a method that can stably and efficiently manufacture IgG antibodies for a T-cell-independent antigen. In said method, DNA that codes for an IgG antibody for the T-cell-independent antigen is inserted into a silkworm, creating a genetically modified silkworm, and the IgG antibodies for the T-cell-independent antigen that are produced by the genetically modified silkworm are collected. The aforementioned DNA contains a DNA sequence consisting of the following DNA sequences joined together: a DNA sequence that codes for a heavy-chain variable region that includes a heavy-chain complementarity determining region of an IgM antibody for the T-cell-independent antigen; and a DNA sequence that codes for a heavy-chain constant region of the IgG antibody. The abovementioned DNA inserted into the silkworm also contains a DNA sequence consisting of the following DNA sequences joined together: a DNA sequence that codes for a light-chain variable region that includes a light-chain complementarity determining
- 来源网站：
- 中国工程科技知识中心
