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Cationic lipids
专利权人:
Asier Unciti-Broceta
发明人:
Asier Unciti-Broceta,Aleksandra Liberska,Mark Bradley
申请号:
US13698804
公开号:
US08759104B2
申请日:
2011.05.17
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention provides a cationic lipid comprising:(i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a cationic precursor(ii) a linking moiety of formula (5):—(HNR5)2NC(O)R3C(O)—  (5),wherein:each R5 is independently an optionally substituted C1-4 alkylene moiety andR3 is an optionally substituted alkylene or alkenylene moiety and(iii) two lipophilic moieties,wherein the head group and each of the lipophilic moieties are connected to the linking moiety through amide linkages.
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