Dosage compensating transgenes and cells

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专利权人:

University of Massachusetts

发明人:

Lawrence Jeanne B.,Jiang Jun,Hall Lisa L.

申请号：

US201414776672

公开号：

US10004765(B2)

申请日:

2014.03.14

申请国别(地区):

美国

年份:

2018

代理人:

Fish & Richardson P.C.

摘要：

Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/