The invention provides methods for modulating the activity of farnesoid X receptors (FXRs) using specific FXR agonists, in particular for treating or preventing liver diseases and disorders.本發明提供使用特定法尼酯X受體(farnesoid X receptor,FXR)促效劑調節FXR之活性、具體而言用於治療或預防肝疾病及病症之方法。