MCBRIDE, WILLIAM J.,D'SOUZA, CHRISTOPHER A.,CHANG, CHIEN-HSING,GOLDENBERG, DAVID M.
申请号：
CA2782398
公开号：
CA2782398C
申请日:
2010.12.09
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct； b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties.
