BELL IAN M.,FRALEY MARK E.,GALLICCHIO STEVEN N.,GINNETTI ANTHONY,MITCHELL HELEN J.,PAONE DANIEL V.,STAAS DONNETTE D.,WANG CHENG,ZARTMAN C. BLAIR,STEVENSON HEATHER E.
申请号：
NZ61046811
公开号：
NZ610468A
申请日:
2011.11.10
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are spiro condensed piperidinone azaindane pyrrolo pyridine carboxamide derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. An example of such a compound is (6S)-N-[(3S,5S,6R)-6-Methyl-5-(2-methylphenyl)-2-oxo-1-(2,2,2-trifluoroethyI)piperidin-3-yl]-2&rsquo-oxo-1&rsquo,2&rsquo,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3&rsquo-pyrrolo [2,3-b]pyridine]-3-carboxamide. Also disclosed is the use of said compounds in the manufacture of a medicament for the prevention or treatment of diseases in which CGRP is involved, for example migraines.
