The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Stanislaw J Kaczmarczyk,Deb K. Chatterjee
申请号：
US14388441
公开号：
US09506041B2
申请日:
2013.03.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Described herein are compositions relating to alphavirus-based virus-like particles (VLPs) and methods for making and using the described VLPs. The described compositions include VLPs and vectors and cells used to produce the VLPs. Also included are related methods to produce the VLPs, to transduce cells using the VLPs, and to produce a protein or polynucleotide of interest in a target cell using the VLPs. Also described are alphavirus-based replicons that allow for expression of proteins or polynucleotides of interest in a target cell without a cytopathic effect.
