The invention relates to an ophthalmic depot formulation containing benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethylsulfoxide wherein the volume ratio of benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethylsulfoxide in the ophthalmic depot formulation is 75:25-25:75, and the ophthalmic depot formulation contains a total of 50% (w/w) or more of benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethylsulfoxide.