A complex is reported herein which comprises as antibody as a first portion an antibody-derived portion that specifically binds a target antigen and comprises as a second portion a virus-derived peptide linked to an MHC class I protein complex. By using the complexes as reported herein, existing virus-specific circulating cytotoxic T-cells (T-memory cells or T-effector cells) of an individual can be transferred to MHC class I complexes that mimic acute viral infection. By decorating, the antibody-derived portion of the covalent complex can be directed to a cell expressing a target antigen to which it specifically binds. Thus, one aspect as reported herein comprises (i) the β2-microglobulin and (ii) the extracellular domains α1, α2 and α3 of MHC class I molecules having a relative frequency of less than 1%, or (i) virus- One fusion comprising the derived peptide, (ii) β2-microglobulin and (iii) the extracellular domains α1, α2 and α3 of the MHC class I molecule with a relative frequency of at least 1% in the N-terminus to the C-terminus direction A polypeptide, and two polypeptide chains linked by one or more disulfide bonds, wherein the first disulfide-linked polypeptide chain is (i) an immunoglobulin light chain or heavy chain variable domain, (ii) an immunoglobulin light chain or heavy chain The constant domain and (iii) the antibody heavy chain hinge region polypeptide in an N-terminus to C-terminal direction, and wherein the second disulfide-linked polypeptide chain is an antibody heavy chain hinge region polypeptide A heavy chain comprising a fusion polypeptide covalently linked to the C-terminus or N-terminus of one of the disulfide-linked polypeptide chains or complementary to a heavy or light chain variable domain included in a first disulfide-linked polypeptide chain Or a covalently bonded to the N-terminus of the antibody variable domain as the light chain variable domain.표적 항원에 특이적으로 결합하는 항체-유래된 부분을 제1 부분으로서 포함하고 MHC 클래스 I 단백질 복합체에 연결된 바이러스-유래된 펩티드를 제2 부분
