KIM, Myeong-Seop,KIM, Sumin,KIM, Jin Kwan,KIM, Hadong,RYU, Ki Moon,PARK, Seong Jin,PARK, Taesun,SHEEN, Joon-Ho,YOON, Taeyoung,JANG, Mi Yeon
申请号：
PE2018000308
公开号：
PE20181017A1
申请日:
2016.08.31
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The invention refers to a heterocyclic compound represented by a formula, wherein X is CR7 or N, y is ch8, nr8 u, Z is CH2, CH2O, C (= O),Among other things, R1 is h, halogen, C1-C4 tar； R2 is halogen, C1-C4 tar, C1-C2 lease, etc.； R3 is halogen, CN, arilo, etc.； R4 and R5 are h, C1-C6 tar, C1-C6 tar, etc.； r5'es h, or can combine with R5 to form carbon； R6 es H, C1-C4, C1-C6, among others； R7 is h, halogen or C1-C3 tar； R8 is h, C1-C6 tar, C1-C4 fluorine tar. The most popular compounds are: 2-amine-n - ((1s, 2S) - 2 - (benciloxi) cyclopentanediol) - 5 - (1-methyl-1h-pirazol-4-il) nicotine, 2-amine-n - ((1R, 2S) - 2 - (benciloxi) cyclopentanediol) - 5 - (1-methyl-1h-pirazol-4-il) nicotine,There are others It also refers to heterocyclic compounds, stereoisomers of these compounds, counterparts of these compounds or salts with stable efficacy of these compounds, and the efficacy of stable efficacy vehicles. The present invention is useful for the prevention or treatment of diseases affected by adrenaline inhibition, such as blood cells, colon cancer, lung cancer, etc.La presente invencion refiere un compuesto heterociclico representado por la formula I, donde: X es CR7 o N； Y es CHR8, NR8 u O； Z es CH2, CH2O, C(=O), entre otros； R1 es H, halogeno, alquilo C1-C4, entre otros； R2 es halogeno, alquilo C1-C4, alquilarilo C1-C2, entre otros； R3 es halogeno, CN, arilo, entre otros； R4 y R5 son cada uno en forma independiente H, alquilo C1-C6, alcoxi C1-C6, entre otros； R5' es H o se puede combinar con R5 para formar un carbonilo； R6 es H, alquilo C1-C4, alcoxi C1-C6, entre otros； R7 es H, halogeno o alquilo C1-C3； R8 es H, alquilo C1-C6, fluoroalquilo C1-C4, entre otros. Son compuesto preferidos: 2-amino-N-((1S, 2S)-2-(benciloxi)ciclopentil)-5-(1-metil-1H-pirazol-4-il)nicotinamida, 2-amino-N-((1R, 2S)-2-(benciloxi)ciclopentil)-5-(1-metil-1H-pirazol-4-il)nicotinamida, entre otros. Tambien refiere a composiciones farmaceuticas que comprenden los compuestos heterociclicos, el
