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T細胞輸送治療分子的組合物和方法
专利权人:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人:
ZHAO, Yangbing,JUNE, Carl, H.,LIU, Xiaojun
申请号:
HK18107238
公开号:
HK1247957A1
申请日:
2018.06.01
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
The present invention includes compositions and methods for modifying a T cell with a nucleic acid encoding a switch molecule comprising an extracellular domain comprising a membrane receptor or fragment thereof and an intracellular domain comprising a signaling receptor or fragment thereof. In one aspect, a method comprises introducing a nucleic acid encoding a switch molecule and a nucleic acid encoding a soluble fusion protein and/or a nucleic acid encoding a bispecific antibody into a population of cells comprising T cells, wherein the T cells transiently expresses the switch molecule and soluble fusion protein or bispecific antibody. In other aspect, compositions of T cells and methods of treating a disease or condition, such as cancer or an autoimmune disease, are also included.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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