PROBLEM TO BE SOLVED: To estimate a threshold value of stimulation intensity by which stimulation induces reaction in a living body.SOLUTION: A threshold value estimation device 101 is configured so that: a setting unit 102 sets an initial value of intensity to each electrode; a selection unit 103 selects an electrode to which a threshold value is not estimated, randomly; a stimulation unit 104 gives stimulation having the intensity with respect to the electrode, to a living body via the selected electrode; a detection unit 105 detects presence/absence of reaction which is induced by the stimulation; an update unit 106 increases or decreased the intensity corresponding to the selected electrode, based on presence/absence of detected reaction; an estimation unit 107 estimates a converged value as a threshold value corresponding to the electrode, when the updated intensity corresponding to each electrode satisfies a convergence condition. The threshold value estimation device 101 repeats processing on each unit, until all threshold values corresponding to each of electrodes are estimated. Based on whether the electrodes selected continuously are the same electrode or not, a time interval between previous stimulation and subsequent stimulation is adjusted.SELECTED DRAWING: Figure 1