LIPP MICHAEL M.,리프, 마이클, 엠.,BATYCKY RICHARD P.,배타이키, 리차드, 피.
申请号：
KR1020157015346
公开号：
KR1020150108816A
申请日:
2013.11.08
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The invention relates to a dosator which comprises a tapered elongate cavity； a stationary plunger disposed within the cavity； a removable mesh screen disposed between the stationary plunger and the bottom of the dosator； a dosator chamber defined between the mesh screen and the bottom of the dosator for receiving powder from a powder source and holding the powder until it is expelled into the capsule； at least one vacuum pump operably linked to the dosator and capable of drawing dry powder into the dosator chamber from a powder source, compacting the powder into a slug of powder having a predetermined bulk density； and at least one source of positive pressure operably linked to the dosator and capable of providing positive pressure to expel the powder slug from the dosator and methods of filling capsules.본 발명은, 약 5㎛ 초과의 기하학적 크기와 약 0.075 g/㎤ 미만의 탭 밀도를 지니고 약제학적 제제를 함유하는 입자들을 포함하는, 폐 전달용의 약제학적 조성물을 제공한다. 본 발명은 또한 본 발명의 약제학적 조성물을 환자의 호흡기에 전달하는 방법을 제공한다.
