Disclosed is an antiseptic cap for a catheter access site to maintain sterility of the thread connection. The antiseptic cap comprises a housing having a generally cylindrical side wall defining a chamber having an open upper end and an end wall closing the opposite end. The generally cylindrical side wall has an inner surface with threads extending along a portion of the inner surface. An antiseptic material is coated on the inner surface of the generally cylindrical side wall and an antiseptic coating is on an external surface of the generally cylindrical side wall. An actuating post extends from the end wall of the housing, the actuating post having an antiseptic coating thereon. The antiseptic material is coated on the inner surface of the generally cylindrical side wall by immersion of the inner surface into an antiseptic solution or by spray coating the inner surface with an antiseptic solution, or by blending an antiseptic solution or material into a polymeric material and forming the inner surface therefrom.
