NARAYANAN RAMESH,MILLER DUANE D,PONNUSAMY THAMARAI,HWANG DONG JIN,DUKE CHARLES B,COSS CHRISTOPHER C,JONES AMANDA,DALTON JAMES T
申请号：
IN201717041606
公开号：
IN201717041606A
申请日:
2017.11.21
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
This invention provides novel 3 amino propanamide selective androgen receptor degrader (SARD) compounds pharmaceutical compositions and uses thereof in treating prostate cancer advanced prostate cancer castration resistant prostate cancer androgenic alopecia or other hyperandrogenic dermal diseases Kennedy s disease amyotrophic lateral sclerosis (ALS) and uterine fibroids and to methods for reducing the levels of androgen receptor full length (AR FL) including pathogenic or resistance mutations AR splice variants (AR SV) and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
