KRISTIANSEN, KARSTEN,MAINKAR, PRATHAMA S.,MEYER, JEAN-PHILIPPE,SANTANA SORENSEN, ALEXANDRA
申请号：
ES07804876
公开号：
ES2533652T3
申请日:
2007.01.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A 1,3-dioxane derivative or a pharmaceutically acceptable salt thereof for use in the treatment of a disease or condition sensitive to the receptor-activated peroxisome proliferator (PPAR) selected from insulin resistance, diabetes, metabolic syndrome, obesity, pre-diabetes, diabetes, dyslipidemia, and wound healing, in which the derivative is represented by the formula: ** Formula ** in which A is a linear or branched carbon chain of 3 to 7 carbon atoms with up to 2 double links； W is COOH, OH, NH2, SO3H, OSO3H, or an aromatic group selected from the group consisting of phenyl, 1-naphthyl or 2-naphthyl, pyridine, furan, 2-methylpyridine and a dioxolane, each optionally substituted with COOH , OH or NaH2； Ar is a phenyl, 1-naphthyl, 2-naphthyl, or a 5- or 6-membered aromatic heterocyclic group optionally substituted by hydroxy or methoxy at the ortho, meta and / or para positions； and, Ra and Rb are independently hydrogen, C2-6 alkenyl, C1-8 alkyl optionally substituted with up to three halogen substituents, pentafluorophenyl, aryl or aryl (C1-4) alkyl, said substituents being aryl or aryl (1-4C) alkyl optionally substituted with a maximum of five substituents selected from halogen, (C1-6) alkyl, linear or branched (C1-6) alkoxy, alkylene (C1-4) dioxy, trifluoromethyl, cyano, nitro, hydroxyl, alkanoyloxy (C2-6 ), (C1-6) alkylthio, (C1-6) alkane sulfonyl, (C1-6) alkylamino and oxapolymethylene of 2 to 4 carbon atoms, or Ra and Rb together polymethylene forms of 2 to 7 carbon atoms, which optionally has one or two (C1-4) alkyl substituents.Un derivado de 1,3-dioxano o una de sus sales farmacéuticamente aceptables para su uso en el tratamiento de una enfermedad o afección sensible al receptor activado por el proliferador de peroxisomas (PPAR) seleccionada entre resistencia a la insulina, diabetes, síndrome metabólico, obesidad, pre-diabetes, diabetes, dislipidemia, y cicatrización de heridas, en la que el derivado está representado por la fórmula:**Fórmula** en la que
