Andrew David Abell,James Morriss Coxon,Matthew Alan Jones,Stephen Brian McNabb,Axel Thomas Neffe,Steven Geoffrey Aitken,Blair Gibb Stuart,Janna Marie Nikkel,Joanna Kimberley Duncan,Mutita Klanchantra
申请号：
US12446053
公开号：
US08710178B2
申请日:
2007.10.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.
