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ARYL SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
Xiaojun Zhang,Xiaofan Zheng,Louis S. Chupak
申请号:
US15747218
公开号:
US20180214445A1
申请日:
2016.07.28
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Disclosed is a compound of Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein one R3 is H and the other R3 is an aryl group substituted with zero to 3 R3a; and R1, R2, and R3a are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors for the inhibition or prevention of platelet aggregation, and the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder. Also disclosed are methods of using such compounds for the treatment of human papillomavirus. Additionally, pharmaceutical compositions comprising at least one compound of Formula (I) are disclosed.
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